Hypocalcaemia in patients with metastatic bone disease treated with denosumab.
Identifieur interne : 002C83 ( Main/Exploration ); précédent : 002C82; suivant : 002C84Hypocalcaemia in patients with metastatic bone disease treated with denosumab.
Auteurs : Jean-Jacques Body [Belgique] ; Henry G. Bone [États-Unis] ; Richard H. De Boer [Australie] ; Alison Stopeck [États-Unis] ; Catherine Van Poznak [États-Unis] ; Ronaldo Damião [Brésil] ; Karim Fizazi [France] ; David H. Henry [États-Unis] ; Toni Ibrahim [Italie] ; Allan Lipton [États-Unis] ; Fred Saad [Canada] ; Neal Shore [États-Unis] ; Toshimi Takano [Japon] ; Adam J. Shaywitz [États-Unis] ; Huei Wang [États-Unis] ; Oswaldo L. Bracco [États-Unis] ; Ada Braun [États-Unis] ; Paul J. Kostenuik [États-Unis]Source :
- European journal of cancer (Oxford, England : 1990) [ 1879-0852 ] ; 2015.
Descripteurs français
- KwdFr :
- Agents de maintien de la densité osseuse (effets indésirables), Antinéoplasiques (effets indésirables), Calcium (sang), Carence en vitamine D (), Carence en vitamine D (diagnostic), Diphosphonates (effets indésirables), Dénosumab (effets indésirables), Essais cliniques de phase III comme sujet, Facteurs de risque, Facteurs temps, Humains, Hypocalcémie (), Hypocalcémie (diagnostic), Hypocalcémie (sang), Hypocalcémie (épidémiologie), Imidazoles (effets indésirables), Incidence, Indice de gravité médicale, Marqueurs biologiques (sang), Résultat thérapeutique, Tumeurs osseuses (secondaire), Tumeurs osseuses (traitement médicamenteux), Études rétrospectives, Évaluation des risques.
- MESH :
- diagnostic : Carence en vitamine D, Hypocalcémie.
- effets indésirables : Agents de maintien de la densité osseuse, Antinéoplasiques, Diphosphonates, Dénosumab, Imidazoles.
- sang : Calcium, Hypocalcémie, Marqueurs biologiques.
- secondaire : Tumeurs osseuses.
- traitement médicamenteux : Tumeurs osseuses.
- épidémiologie : Hypocalcémie.
- Carence en vitamine D, Essais cliniques de phase III comme sujet, Facteurs de risque, Facteurs temps, Humains, Hypocalcémie, Incidence, Indice de gravité médicale, Résultat thérapeutique, Études rétrospectives, Évaluation des risques.
English descriptors
- KwdEn :
- Antineoplastic Agents (adverse effects), Biomarkers (blood), Bone Density Conservation Agents (adverse effects), Bone Neoplasms (drug therapy), Bone Neoplasms (secondary), Calcium (blood), Clinical Trials, Phase III as Topic, Denosumab (adverse effects), Diphosphonates (adverse effects), Humans, Hypocalcemia (blood), Hypocalcemia (chemically induced), Hypocalcemia (diagnosis), Hypocalcemia (epidemiology), Hypocalcemia (prevention & control), Imidazoles (adverse effects), Incidence, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors, Treatment Outcome, Vitamin D Deficiency (complications), Vitamin D Deficiency (diagnosis).
- MESH :
- chemical , adverse effects : Antineoplastic Agents, Bone Density Conservation Agents, Denosumab, Diphosphonates, Imidazoles.
- chemical , blood : Biomarkers, Calcium.
- blood : Hypocalcemia.
- chemically induced : Hypocalcemia.
- complications : Vitamin D Deficiency.
- diagnosis : Hypocalcemia, Vitamin D Deficiency.
- drug therapy : Bone Neoplasms.
- epidemiology : Hypocalcemia.
- prevention & control : Hypocalcemia.
- secondary : Bone Neoplasms.
- Clinical Trials, Phase III as Topic, Humans, Incidence, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors, Treatment Outcome.
Abstract
This analysis was performed to further characterise treatment-emergent hypocalcaemia in patients with bone metastases receiving denosumab.
DOI: 10.1016/j.ejca.2015.05.016
PubMed: 26093811
Affiliations:
- Australie, Belgique, Brésil, Canada, France, Italie, Japon, États-Unis
- Californie, Caroline du Sud, Michigan, Pennsylvanie, Région de Bruxelles-Capitale, Région de Kantō, État de New York, État de Rio de Janeiro
- Bruxelles, Rio de Janeiro, Tokyo, University Park (Pennsylvanie)
- Université d'État de Pennsylvanie, Université libre de Bruxelles
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Le document en format XML
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Electronic address: jean-jacques.body@chu-brugmann.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Bone, Henry G" sort="Bone, Henry G" uniqKey="Bone H" first="Henry G" last="Bone">Henry G. Bone</name><affiliation wicri:level="2"><nlm:affiliation>Michigan Bone and Mineral Clinic, Detroit, MI, USA. Electronic address: hgbone.md@att.net.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Michigan Bone and Mineral Clinic, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="De Boer, Richard H" sort="De Boer, Richard H" uniqKey="De Boer R" first="Richard H" last="De Boer">Richard H. De Boer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Royal Melbourne Hospital, Melbourne, VIC, Australia. Electronic address: richard.deboer@wh.org.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Royal Melbourne Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Stopeck, Alison" sort="Stopeck, Alison" uniqKey="Stopeck A" first="Alison" last="Stopeck">Alison Stopeck</name><affiliation wicri:level="2"><nlm:affiliation>Stony Brook Cancer Center, Stony Brook, NY, USA. Electronic address: Alison.Stopeck@stonybrookmedicine.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stony Brook Cancer Center, Stony Brook, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Van Poznak, Catherine" sort="Van Poznak, Catherine" uniqKey="Van Poznak C" first="Catherine" last="Van Poznak">Catherine Van Poznak</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA. Electronic address: cvanpoz@med.umich.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Damiao, Ronaldo" sort="Damiao, Ronaldo" uniqKey="Damiao R" first="Ronaldo" last="Damião">Ronaldo Damião</name><affiliation wicri:level="3"><nlm:affiliation>Department of Urology, Hospital Universitario Pedro Ernesto, Rio de Janeiro, Brazil. Electronic address: damiao@email.com.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Urology, Hospital Universitario Pedro Ernesto, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Fizazi, Karim" sort="Fizazi, Karim" uniqKey="Fizazi K" first="Karim" last="Fizazi">Karim Fizazi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Institut Gustave Roussy, University of Paris Sud, Villejuif, France. Electronic address: Karim.FIZAZI@igr.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Institut Gustave Roussy, University of Paris Sud, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Henry, David H" sort="Henry, David H" uniqKey="Henry D" first="David H" last="Henry">David H. Henry</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Joan Karnell Cancer Center at Pennsylvania Hospital, Philadelphia, PA, USA. Electronic address: dhhenry@juno.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Joan Karnell Cancer Center at Pennsylvania Hospital, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ibrahim, Toni" sort="Ibrahim, Toni" uniqKey="Ibrahim T" first="Toni" last="Ibrahim">Toni Ibrahim</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS-Osteoncology and Rare Tumors Center, Meldola, Italy. Electronic address: toni.ibrahim@irst.emr.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS-Osteoncology and Rare Tumors Center, Meldola</wicri:regionArea><wicri:noRegion>Meldola</wicri:noRegion></affiliation></author><author><name sortKey="Lipton, Allan" sort="Lipton, Allan" uniqKey="Lipton A" first="Allan" last="Lipton">Allan Lipton</name><affiliation wicri:level="4"><nlm:affiliation>Division of Oncology, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA, USA. Electronic address: alipton@hmc.psu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Oncology, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation></author><author><name sortKey="Saad, Fred" sort="Saad, Fred" uniqKey="Saad F" first="Fred" last="Saad">Fred Saad</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, University of Montreal Hospital Center, Montreal, QC, Canada. Electronic address: fredsaad@videotron.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Montreal Hospital Center, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Shore, Neal" sort="Shore, Neal" uniqKey="Shore N" first="Neal" last="Shore">Neal Shore</name><affiliation wicri:level="2"><nlm:affiliation>Department of Urology, Carolina Urologic Research Center, Myrtle Beach, SC, USA. Electronic address: nshore@gsuro.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Urology, Carolina Urologic Research Center, Myrtle Beach, SC</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Takano, Toshimi" sort="Takano, Toshimi" uniqKey="Takano T" first="Toshimi" last="Takano">Toshimi Takano</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan. Electronic address: takano@toranomon.gr.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medical Oncology, Toranomon Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Shaywitz, Adam J" sort="Shaywitz, Adam J" uniqKey="Shaywitz A" first="Adam J" last="Shaywitz">Adam J. Shaywitz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: ashaywitz@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wang, Huei" sort="Wang, Huei" uniqKey="Wang H" first="Huei" last="Wang">Huei Wang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: hueiw@amgen.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bracco, Oswaldo L" sort="Bracco, Oswaldo L" uniqKey="Bracco O" first="Oswaldo L" last="Bracco">Oswaldo L. Bracco</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: ozzie.bracco@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Braun, Ada" sort="Braun, Ada" uniqKey="Braun A" first="Ada" last="Braun">Ada Braun</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: adahbraun@yahoo.de.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kostenuik, Paul J" sort="Kostenuik, Paul J" uniqKey="Kostenuik P" first="Paul J" last="Kostenuik">Paul J. Kostenuik</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: PKost@roadrunner.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26093811</idno><idno type="pmid">26093811</idno><idno type="doi">10.1016/j.ejca.2015.05.016</idno><idno type="wicri:Area/PubMed/Corpus">002962</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002962</idno><idno type="wicri:Area/PubMed/Curation">002893</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002893</idno><idno type="wicri:Area/PubMed/Checkpoint">002893</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002893</idno><idno type="wicri:Area/Ncbi/Merge">002733</idno><idno type="wicri:Area/Ncbi/Curation">002733</idno><idno type="wicri:Area/Ncbi/Checkpoint">002733</idno><idno type="wicri:Area/Main/Merge">002C83</idno><idno type="wicri:Area/Main/Curation">002C83</idno><idno type="wicri:Area/Main/Exploration">002C83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hypocalcaemia in patients with metastatic bone disease treated with denosumab.</title><author><name sortKey="Body, Jean Jacques" sort="Body, Jean Jacques" uniqKey="Body J" first="Jean-Jacques" last="Body">Jean-Jacques Body</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: jean-jacques.body@chu-brugmann.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Bone, Henry G" sort="Bone, Henry G" uniqKey="Bone H" first="Henry G" last="Bone">Henry G. Bone</name><affiliation wicri:level="2"><nlm:affiliation>Michigan Bone and Mineral Clinic, Detroit, MI, USA. Electronic address: hgbone.md@att.net.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Michigan Bone and Mineral Clinic, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="De Boer, Richard H" sort="De Boer, Richard H" uniqKey="De Boer R" first="Richard H" last="De Boer">Richard H. De Boer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Royal Melbourne Hospital, Melbourne, VIC, Australia. Electronic address: richard.deboer@wh.org.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Royal Melbourne Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Stopeck, Alison" sort="Stopeck, Alison" uniqKey="Stopeck A" first="Alison" last="Stopeck">Alison Stopeck</name><affiliation wicri:level="2"><nlm:affiliation>Stony Brook Cancer Center, Stony Brook, NY, USA. Electronic address: Alison.Stopeck@stonybrookmedicine.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stony Brook Cancer Center, Stony Brook, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Van Poznak, Catherine" sort="Van Poznak, Catherine" uniqKey="Van Poznak C" first="Catherine" last="Van Poznak">Catherine Van Poznak</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA. Electronic address: cvanpoz@med.umich.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Damiao, Ronaldo" sort="Damiao, Ronaldo" uniqKey="Damiao R" first="Ronaldo" last="Damião">Ronaldo Damião</name><affiliation wicri:level="3"><nlm:affiliation>Department of Urology, Hospital Universitario Pedro Ernesto, Rio de Janeiro, Brazil. Electronic address: damiao@email.com.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Urology, Hospital Universitario Pedro Ernesto, Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Fizazi, Karim" sort="Fizazi, Karim" uniqKey="Fizazi K" first="Karim" last="Fizazi">Karim Fizazi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Institut Gustave Roussy, University of Paris Sud, Villejuif, France. Electronic address: Karim.FIZAZI@igr.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Institut Gustave Roussy, University of Paris Sud, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Henry, David H" sort="Henry, David H" uniqKey="Henry D" first="David H" last="Henry">David H. Henry</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Joan Karnell Cancer Center at Pennsylvania Hospital, Philadelphia, PA, USA. Electronic address: dhhenry@juno.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Joan Karnell Cancer Center at Pennsylvania Hospital, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ibrahim, Toni" sort="Ibrahim, Toni" uniqKey="Ibrahim T" first="Toni" last="Ibrahim">Toni Ibrahim</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS-Osteoncology and Rare Tumors Center, Meldola, Italy. Electronic address: toni.ibrahim@irst.emr.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS-Osteoncology and Rare Tumors Center, Meldola</wicri:regionArea><wicri:noRegion>Meldola</wicri:noRegion></affiliation></author><author><name sortKey="Lipton, Allan" sort="Lipton, Allan" uniqKey="Lipton A" first="Allan" last="Lipton">Allan Lipton</name><affiliation wicri:level="4"><nlm:affiliation>Division of Oncology, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA, USA. Electronic address: alipton@hmc.psu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Oncology, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation></author><author><name sortKey="Saad, Fred" sort="Saad, Fred" uniqKey="Saad F" first="Fred" last="Saad">Fred Saad</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, University of Montreal Hospital Center, Montreal, QC, Canada. Electronic address: fredsaad@videotron.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Montreal Hospital Center, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Shore, Neal" sort="Shore, Neal" uniqKey="Shore N" first="Neal" last="Shore">Neal Shore</name><affiliation wicri:level="2"><nlm:affiliation>Department of Urology, Carolina Urologic Research Center, Myrtle Beach, SC, USA. Electronic address: nshore@gsuro.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Urology, Carolina Urologic Research Center, Myrtle Beach, SC</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Takano, Toshimi" sort="Takano, Toshimi" uniqKey="Takano T" first="Toshimi" last="Takano">Toshimi Takano</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan. Electronic address: takano@toranomon.gr.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medical Oncology, Toranomon Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Shaywitz, Adam J" sort="Shaywitz, Adam J" uniqKey="Shaywitz A" first="Adam J" last="Shaywitz">Adam J. Shaywitz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: ashaywitz@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wang, Huei" sort="Wang, Huei" uniqKey="Wang H" first="Huei" last="Wang">Huei Wang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: hueiw@amgen.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bracco, Oswaldo L" sort="Bracco, Oswaldo L" uniqKey="Bracco O" first="Oswaldo L" last="Bracco">Oswaldo L. Bracco</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: ozzie.bracco@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Braun, Ada" sort="Braun, Ada" uniqKey="Braun A" first="Ada" last="Braun">Ada Braun</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: adahbraun@yahoo.de.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kostenuik, Paul J" sort="Kostenuik, Paul J" uniqKey="Kostenuik P" first="Paul J" last="Kostenuik">Paul J. Kostenuik</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA, USA. Electronic address: PKost@roadrunner.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology/Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">European journal of cancer (Oxford, England : 1990)</title><idno type="eISSN">1879-0852</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (adverse effects)</term><term>Biomarkers (blood)</term><term>Bone Density Conservation Agents (adverse effects)</term><term>Bone Neoplasms (drug therapy)</term><term>Bone Neoplasms (secondary)</term><term>Calcium (blood)</term><term>Clinical Trials, Phase III as Topic</term><term>Denosumab (adverse effects)</term><term>Diphosphonates (adverse effects)</term><term>Humans</term><term>Hypocalcemia (blood)</term><term>Hypocalcemia (chemically induced)</term><term>Hypocalcemia (diagnosis)</term><term>Hypocalcemia (epidemiology)</term><term>Hypocalcemia (prevention & control)</term><term>Imidazoles (adverse effects)</term><term>Incidence</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Treatment Outcome</term><term>Vitamin D Deficiency (complications)</term><term>Vitamin D Deficiency (diagnosis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents de maintien de la densité osseuse (effets indésirables)</term><term>Antinéoplasiques (effets indésirables)</term><term>Calcium (sang)</term><term>Carence en vitamine D ()</term><term>Carence en vitamine D (diagnostic)</term><term>Diphosphonates (effets indésirables)</term><term>Dénosumab (effets indésirables)</term><term>Essais cliniques de phase III comme sujet</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Humains</term><term>Hypocalcémie ()</term><term>Hypocalcémie (diagnostic)</term><term>Hypocalcémie (sang)</term><term>Hypocalcémie (épidémiologie)</term><term>Imidazoles (effets indésirables)</term><term>Incidence</term><term>Indice de gravité médicale</term><term>Marqueurs biologiques (sang)</term><term>Résultat thérapeutique</term><term>Tumeurs osseuses (secondaire)</term><term>Tumeurs osseuses (traitement médicamenteux)</term><term>Études rétrospectives</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Agents</term><term>Bone Density Conservation Agents</term><term>Denosumab</term><term>Diphosphonates</term><term>Imidazoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Calcium</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hypocalcemia</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Hypocalcemia</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Vitamin D Deficiency</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypocalcemia</term><term>Vitamin D Deficiency</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Carence en vitamine D</term><term>Hypocalcémie</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bone Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Agents de maintien de la densité osseuse</term><term>Antinéoplasiques</term><term>Diphosphonates</term><term>Dénosumab</term><term>Imidazoles</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hypocalcemia</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Hypocalcemia</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Calcium</term><term>Hypocalcémie</term><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs osseuses</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Bone Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs osseuses</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Hypocalcémie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Clinical Trials, Phase III as Topic</term><term>Humans</term><term>Incidence</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Carence en vitamine D</term><term>Essais cliniques de phase III comme sujet</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Humains</term><term>Hypocalcémie</term><term>Incidence</term><term>Indice de gravité médicale</term><term>Résultat thérapeutique</term><term>Études rétrospectives</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This analysis was performed to further characterise treatment-emergent hypocalcaemia in patients with bone metastases receiving denosumab.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Brésil</li><li>Canada</li><li>France</li><li>Italie</li><li>Japon</li><li>États-Unis</li></country><region><li>Californie</li><li>Caroline du Sud</li><li>Michigan</li><li>Pennsylvanie</li><li>Région de Bruxelles-Capitale</li><li>Région de Kantō</li><li>État de New York</li><li>État de Rio de Janeiro</li></region><settlement><li>Bruxelles</li><li>Rio de Janeiro</li><li>Tokyo</li><li>University Park (Pennsylvanie)</li></settlement><orgName><li>Université d'État de Pennsylvanie</li><li>Université libre de Bruxelles</li></orgName></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Body, Jean Jacques" sort="Body, Jean Jacques" uniqKey="Body J" first="Jean-Jacques" last="Body">Jean-Jacques Body</name></region></country><country name="États-Unis"><region name="Michigan"><name sortKey="Bone, Henry G" sort="Bone, Henry G" uniqKey="Bone H" first="Henry G" last="Bone">Henry G. Bone</name></region><name sortKey="Bracco, Oswaldo L" sort="Bracco, Oswaldo L" uniqKey="Bracco O" first="Oswaldo L" last="Bracco">Oswaldo L. Bracco</name><name sortKey="Braun, Ada" sort="Braun, Ada" uniqKey="Braun A" first="Ada" last="Braun">Ada Braun</name><name sortKey="Henry, David H" sort="Henry, David H" uniqKey="Henry D" first="David H" last="Henry">David H. Henry</name><name sortKey="Kostenuik, Paul J" sort="Kostenuik, Paul J" uniqKey="Kostenuik P" first="Paul J" last="Kostenuik">Paul J. Kostenuik</name><name sortKey="Lipton, Allan" sort="Lipton, Allan" uniqKey="Lipton A" first="Allan" last="Lipton">Allan Lipton</name><name sortKey="Shaywitz, Adam J" sort="Shaywitz, Adam J" uniqKey="Shaywitz A" first="Adam J" last="Shaywitz">Adam J. Shaywitz</name><name sortKey="Shore, Neal" sort="Shore, Neal" uniqKey="Shore N" first="Neal" last="Shore">Neal Shore</name><name sortKey="Stopeck, Alison" sort="Stopeck, Alison" uniqKey="Stopeck A" first="Alison" last="Stopeck">Alison Stopeck</name><name sortKey="Van Poznak, Catherine" sort="Van Poznak, Catherine" uniqKey="Van Poznak C" first="Catherine" last="Van Poznak">Catherine Van Poznak</name><name sortKey="Wang, Huei" sort="Wang, Huei" uniqKey="Wang H" first="Huei" last="Wang">Huei Wang</name></country><country name="Australie"><noRegion><name sortKey="De Boer, Richard H" sort="De Boer, Richard H" uniqKey="De Boer R" first="Richard H" last="De Boer">Richard H. De Boer</name></noRegion></country><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Damiao, Ronaldo" sort="Damiao, Ronaldo" uniqKey="Damiao R" first="Ronaldo" last="Damião">Ronaldo Damião</name></region></country><country name="France"><noRegion><name sortKey="Fizazi, Karim" sort="Fizazi, Karim" uniqKey="Fizazi K" first="Karim" last="Fizazi">Karim Fizazi</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Ibrahim, Toni" sort="Ibrahim, Toni" uniqKey="Ibrahim T" first="Toni" last="Ibrahim">Toni Ibrahim</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Saad, Fred" sort="Saad, Fred" uniqKey="Saad F" first="Fred" last="Saad">Fred Saad</name></noRegion></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Takano, Toshimi" sort="Takano, Toshimi" uniqKey="Takano T" first="Toshimi" last="Takano">Toshimi Takano</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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